Potassium Canrenoate and Digitalis Intoxication

Reference 1 is to Campbell's Letter to the Editor and reference 2 is to Pettinger et al., Am J Physiol 225: 234238, 1973. *P < 0.025 compared with value in 3-week-old spontaneously hypertensive rats. nous substrate and did not demonstrate that substrate remained in excess during that entire period, and (2) they did not use angiotensinase inhibitors during incubation. Incidentally, De Jong et al. (Proc Soc Exp Biol Med 139:1213-1216, 1972) have also shown an increased plasma renin activity in unanesthetized, decapitated spontaneously hypertensive rats. I have no comments on Dr. Campbell's speculation that spontaneously hypertensive rats are more prone to release renin under anesthesia than are normotensive rats, since I have no data on unanesthetized rats. However, before accepting this theory, further experimentation is required.