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The effects of norepinephrine, theophylline, and adrenergic blocking drugs on renin release from rat kidney slices were studied in vitro. l-Norepinephrine increased renin release into the incubation medium; this increase was accompanied by an increase in the renin content of the slices. Statistically significant increases in renin release were produced by 10−5M and 2 × 10−5M l-norepinephrine. d-Norepinephrine in the same doses was ineffective. Theophylline (10−3M) had no effect by itself, but it potentiated the effect of l-norepinephrine on renin release. The response to l-norepinephrine was markedly suppressed by l-propranolol (10−4M) but not by d-propranolol (10−4M). The α-receptor blocking agents phentolamine (10−4M) and phenoxybenzamine (10−4M) increased rather than decreased the effect of l-norepinephrine. These results are consistent with a direct intrarenal effect of norepinephrine on renin release; this effect appears to be mediated by a β-adrenergic mechanism.

Effect of Theophylline and Adrenergic Blocking Drugs on the Renin Response to Norepinephrine In Vitro