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The response of arterial pressure to very rapid central venous bleeding has been utilized in an attempt to establish an arterial pressure-volume relation in the intact dog. When dogs were bled for a brief period at rates between 200 and 500 cc. per minute the arterial pressure declined as a rectilinear function of the bleeding volume. The compensatory mechanisms of cardiac acceleration and vasoconstriction do not influence this relationship. Abolition of the vasomotor pathways does, however, increase the slope of the blood pressure decline curve. This is explained on the basis of a decrease in the initial volume of the arterial reservoir.

An Attempt to Demonstrate Arterial Pressure-Volume Relationships in the Intact Dog by an Ultra-Rapid Bleeding Technic