Open AccessDetection of Preformed Venous Thrombi in Dogs by Means of I 131 -Labeled Antibodies to Dog Fibrinogen
Author(s) -
Irving L. Spar,
Ruth L. Goodland,
Seymour I. Schwartz
Publication year - 1965
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/01.res.17.4.322
Subject(s) - fibrinogen , lesion , antiserum , antibody , pathology , thrombosis , gamma globulin , globulin , platelet , medicine , immunology
Dogs with thrombin-induced thrombi received I131 rabbit antibody to dog fibrinogen and a day later were given antiserum to the rabbit gamma globulin. Scintillation scanning techniques successfully detected the site of thrombosis. Excision of the thrombi and surrounding blood vessels demonstrated deposition of radioactivity in the lesion. The immunologic removal of the gamma globulin from the circulating blood increased the difference between the radioactivity deposited in the lesion and that present in the blood. This accentuates the lesion and offers potential diagnostic advantage.
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