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Some of the factors that influence the contours and time components of indicator-dilution curves have been examined in dogs and man. These include the dynamic-response characteristics of the sampling-detecting-recording system, variations in the sampling site, quantity of blood and rate of blood flow between injection and sampling sites, vascular obstruction, and local and general alterations in peripheral blood flow. Any or all of these factors may be of importance in the interpretation of changes in indicator-dilution curves in patients with congenital or acquired heart disease.

Special Article: Factors Modifying the Contours of Indicator-Dilution Curves