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To the Editor:We read with great interest the recent article by Bretschneider et al,1 who studied the protease activated receptor (PAR)-1-dependent protein C signaling in vascular smooth muscle cells (VSMCs). These data add another piece of evidence to the emerging concept that the endothelial protein C receptor (EPCR) exerts pleiotropic cellular effects.Previous studies from several laboratories have concluded that EPCR ligation with activated protein C (APC) can lead to the proteolytic cleavage of PAR-1 on the surface of endothelial cells (ECs), leading …

The Endothelial Protein C Receptor in Vascular Smooth Muscle Cells For Good or Bad?