English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Deoxycorticosterone (DOC) hypertension in the rat is generally induced in rats at an age of approximately 3 months. Both uninephrectomy and a high sodium diet are necessary, however, to induce DOC hypertension. Considering the inability of the developing kidney to adequately excrete a sodium load, we studied the possibility that DOC alone might induce hypertension when treatment is initiated in rats at the age of 21 days. The contribution of volume expansion as a factor mediating the pressor response to DOC was assessed in rats given a high sodium diet instead of DOC. Systolic blood pressure increased in DOC-treated rats within 3 weeks. Although systolic blood pressure also increased in rats on a high sodium diet, the increase was transient and of a lesser magnitude than that observed in DOC-treated rats. The rise in blood pressure in both groups of rats was associated with suppression of plasma renin activity and aldosterone concentration. Furthermore, extracellular fluid volume was similarly increased in DOC-treated rats and rats given a high sodium diet. Consistent with these data, DOC-treated rats showed an exaggerated natriuretic response to acute saline loading as compared with a vehicle-treated control group. Discontinuation of DOC treatment after 5 weeks led to normalization of all variables studied including blood pressure. Yet, when DOC was continued for 8 weeks, stopping treatment did not lower blood pressure despite normalization of the renin-angiotensin-aldosterone system and the natriuretic response to saline loading. In contrast, discontinuation of the high sodium diet after 8 weeks normalized blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)

Deoxycorticosterone hypertension in the intact weanling rat without salt loading.