Open AccessG894T Polymorphism in the Endothelial Nitric Oxide Synthase Gene Is Associated With an Enhanced Vascular Responsiveness to Phenylephrine
Author(s) -
Ivan Philip,
Gaëtan Plantefève,
Sandrine VuillaumierBarrot,
Éric Vicaut,
Claude Lemarié,
Daniel Henrion,
Odette Poirier,
Bernard Lévy,
J. M. Desmonts,
Geneviève Durand,
Joëlle Bénessiano
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.24.3096
Subject(s) - medicine , phenylephrine , enos , endocrinology , nitric oxide , nitric oxide synthase , anesthesia , cardiology , blood pressure
Differences in vascular reactivity to phenylephrine (PE) responsiveness have been largely evidenced in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Because nitric oxide (NO) strongly affects modulation of the vascular tone in response to vasopressor agents, we hypothesized that the G894T polymorphism of the endothelial NO synthase gene (eNOS) could be related to changes in the pressor response to PE.
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