Open AccessIntracoronary Flecainide Induces ST Alternans and Reentrant Arrhythmia on Intact Canine Heart
Author(s) -
Hidetada Tachibana,
Michiyasu Yamaki,
Isao Kubota,
Tetsu Watanabe,
Sou Yamauchi,
Hitonobu Tomoike
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.12.1637
Subject(s) - flecainide , medicine , disopyramide , cardiology , sodium channel blocker , repolarization , lidocaine , antiarrhythmic agent , sodium channel , anesthesia , ventricular fibrillation , electrocardiography , atrial fibrillation , heart disease , electrophysiology , sodium , chemistry , organic chemistry
The electrical alternans shown on an ST segment, ST alternans, is known as one of the most important predictors of ventricular fibrillation (VF). It has also been reported that sodium channel inhibition changes action potential configuration, especially on the repolarization phase. Thus, the sodium channel blocker may produce ST alternans and trigger reentrant arrhythmia.
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