Open AccessTenascin-C Is Expressed in Macrophage-Rich Human Coronary Atherosclerotic Plaque
Author(s) -
Kurt Wallner,
Chen Li,
Prediman K. Shah,
Michael C. Fishbein,
James S. Forrester,
Sanjay Kaul,
Behrooz G. Sharifi
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.10.1284
Subject(s) - tenascin c , fibrous cap , in situ hybridization , pathology , extracellular matrix , immunohistochemistry , tenascin , medicine , inflammation , western blot , macrophage , microbiology and biotechnology , zymography , gene isoform , gene expression , matrix metalloproteinase , biology , gene , immunology , fibronectin , biochemistry , in vitro
Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human coronary atherosclerotic plaques.
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