Local Adenovirus-Mediated Transfer of Human Endothelial Nitric Oxide Synthase Reduces Luminal Narrowing After Coronary Angioplasty in Pigs | Zendy

Olivier Varenne | Zendy; Sorin V. Pislaru | Zendy; Hilde Gillijns | Zendy; Natascha Van Pelt | Zendy; Robert D. Gerard | Zendy; Pierre Zoldhelyi | Zendy; Frans Van de Werf | Zendy; Désiré Collen | Zendy; Stefan Janssens | Zendy

Open Access

Local Adenovirus-Mediated Transfer of Human Endothelial Nitric Oxide Synthase Reduces Luminal Narrowing After Coronary Angioplasty in Pigs

Author(s) -

Olivier Varenne,

Sorin V. Pislaru,

Hilde Gillijns,

Natascha Van Pelt,

Robert D. Gerard,

Pierre Zoldhelyi,

Frans Van de Werf,

Désiré Collen,

Stefan Janssens

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.98.9.919

Subject(s) - medicine , endothelial nitric oxide synthase , nitric oxide synthase , nitric oxide , angioplasty , cardiology , nitric oxide synthase type iii , enos

Nitric oxide, synthesized from L-arginine by nitric oxide synthase (NOS), is a vasodilator and inhibits vascular smooth muscle cell (SMC) proliferation and migration. The effects of local NOS gene transfer on restenosis after experimental balloon angioplasty were investigated.

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