Open AccessLocalization of a Gene Responsible for Arrhythmogenic Right Ventricular Dysplasia to Chromosome 3p23
Author(s) -
Ferhaan Ahmad,
Duanxiang Li,
Akihiko Karibe,
Óscar GonzálezLorenzo,
Terry Tapscott,
Rita Hill,
Donald Weilbaecher,
Peter Blackie,
Michael Furey,
Martin J. Gardner,
Linda L. Bachinski,
Robert Roberts
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.98.25.2791
Subject(s) - medicine , arrhythmogenic right ventricular dysplasia , gene , cardiology , chromosome , genetics , dysplasia , cardiomyopathy , heart failure , biology
Arrhythmogenic right ventricular dysplasia (ARVD), a familial cardiomyopathy occurring with a prevalence of 1 in 5000, is characterized by replacement of myocytes with fatty and fibrous tissue. Clinical manifestations include structural and functional abnormalities of the right ventricle and arrhythmias, leading to a sudden death rate of 2.5% per year. Four loci have been mapped, but no gene has been identified as yet.
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