Open AccessIdentification of a Novel Genetic Locus for Familial Cardiac Myxomas and Carney Complex
Author(s) -
Mairead Casey,
Caroline S. Mah,
Andrew Merliss,
Lawrence S. Kirschner,
Susan E. Taymans,
Alfred Denio,
Bruce R. Korf,
Alan D. Irvine,
Anne E. Hughes,
J. Aidan Carney,
Constantine A. Stratakis,
Craig T. Basson
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.98.23.2560
Subject(s) - carney complex , medicine , locus (genetics) , genetic heterogeneity , genetic linkage , genetics , haplotype , disease , intracardiac injection , pathology , gene , biology , genotype , phenotype
Intracardiac myxomas are significant causes of cardiovascular morbidity and mortality through embolic stroke and heart failure. In the autosomal dominant syndrome Carney complex, intracardiac myxomas arise in the setting of lentiginosis and other lesions associated with cutaneous hyperpigmentation, extracardiac myxomas, and nonmyxomatous tumors. Genetic factors that regulate cardiac tumor growth remain unknown.
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