Open AccessHuman Prostaglandin Transporter Gene (hPGT) is Regulated by Fluid Mechanical Stimuli in Cultured Endothelial Cells and Expressed in Vascular Endothelium in Vivo
Author(s) -
James N. Topper,
Jiexing Cai,
George Stavrakis,
Keith R. Anderson,
Elizabeth A. Woolf,
Barbara A. Sampson,
Frederick J. Schöen,
Dean Falb,
Michael A. Gimbrone
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.98.22.2396
Subject(s) - endothelium , downregulation and upregulation , microbiology and biotechnology , medicine , gene expression , tumor necrosis factor alpha , in vivo , endothelial stem cell , biology , immunology , endocrinology , in vitro , gene , biochemistry
biomechanical forces generated by blood flow within the cardiovascular system have been proposed as important modulators of regional endothelial phenotype and function. This process is thought to involve the regulation of vascular gene expression by physiological fluid mechanical stimuli such as fluid shear stresses.
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