Open AccessAdenovirus-Mediated Gene Transfer of the Human Tissue Inhibitor of Metalloproteinase-2 Blocks Vascular Smooth Muscle Cell Invasiveness In Vitro and Modulates Neointimal Development In Vivo
Author(s) -
Linda Cheng,
Giuditta Mantile,
Rebecca Pauly,
Cynthia Nater,
Angelina Felici,
Robert E. Monticone,
Claudio Bilato,
Yehezkiel A. Gluzband,
Michael T. Crow,
William G. StetlerStevenson,
Maurizio C. Capogrossi
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.98.20.2195
Subject(s) - matrix metalloproteinase , vascular smooth muscle , extracellular matrix , medicine , neointima , microbiology and biotechnology , biology , restenosis , stent , smooth muscle
Endovascular injury induced by balloon withdrawal leads to the increased activation of matrix metalloproteinases (MMPs) in the vascular wall, allowing smooth muscle cells (SMCs) to digest the surrounding extracellular matrix (ECM) and migrate from the media into the intima. The objective of this study was to examine the effects of a replication-deficient adenovirus carrying the cDNA for human tissue inhibitor of metalloproteinase-2 (AdCMV.hTIMP-2) on SMC function in vitro and neointimal development in the injured rat carotid artery.
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