Open AccessChronic Amlodipine Treatment During the Development of Heart Failure
Author(s) -
Francis G. Spinale,
Rupak Mukherjee,
R. Stephen Krombach,
Mark J. Clair,
Jennifer W. Hendrick,
Ward V. Houck,
Latha Hebbar,
Scott B. Kribbs,
James L. Zellner,
Michael G. Dodd
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.98.16.1666
Subject(s) - medicine , amlodipine , heart failure , cardiology , stroke volume , hemodynamics , vascular resistance , blood pressure , ejection fraction
This study examined the effects of chronic amlodipine treatment on left ventricular (LV) pump function, systemic hemodynamics, neurohormonal status, and regional blood flow distribution in an animal model of congestive heart failure (CHF) both at rest and with treadmill exercise. In an additional series of in vitro studies, LV myocyte contractile function was examined.
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