Open AccessSynergism Between Platelets and Neutrophils in Provoking Cardiac Dysfunction After Ischemia and Reperfusion
Author(s) -
Allan M. Lefer,
Barry J. Campbell,
Rosario Scalia,
David J. Lefer
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.98.13.1322
Subject(s) - medicine , platelet , ischemia , perfusion , myeloperoxidase , cardiology , cardiac function curve , reperfusion injury , coronary circulation , blood flow , anesthesia , inflammation , heart failure
Neutrophils (PMNs) are known to contribute to both cardiac dysfunction and myocardial necrosis after reperfusion of an ischemic heart. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects of PMNs and platelets separately and together in provoking cardiac dysfunction in isolated perfused rat hearts after ischemia and reperfusion.
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