Open AccessEffect of High- and Low-Molecular-Weight Heparins on Thrombin-Thrombomodulin Interaction and Protein C Activation
Author(s) -
Raimondo De Cristofaro,
Erica De Candia,
Raffaele Landolfi
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.98.13.1297
Subject(s) - thrombomodulin , thrombin , heparin , protein c , low molecular weight heparin , biochemistry , recombinant dna , discovery and development of direct thrombin inhibitors , biophysics , medicine , chemistry , biology , platelet , immunology , gene
Thrombin-thrombomodulin (TM) interaction, which is critical for accelerating the protein C anticoagulant pathway, involves the heparin-like domain of TM. This study was aimed at investigating the possible effect of heparin on thrombin-TM binding and protein C activation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom