Open AccessMyocyte Recovery After Mechanical Circulatory Support in Humans With End-Stage Heart Failure
Author(s) -
Κωνσταντίνα Δίπλα,
Julian A. Mattiello,
Valluvan Jeevanandam,
Steven R. Houser,
Kenneth B. Margulies
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.97.23.2316
Subject(s) - myocyte , medicine , heart failure , circulatory system , cardiology , contraction (grammar) , stimulation , cardiac myocyte , ventricular assist device , contractility , heart transplantation , heart disease , endocrinology
The failing myocardium is characterized by decreased force production, slowed relaxation, and depressed responses to beta-adrenergic stimulation. In some heart failure patients, heart function is so poor that a left ventricular assist device (LVAD) is inserted as a bridge to transplantation. In the present research, we investigated whether circulatory support with an LVAD influenced the functional properties of myocytes from the failing heart.
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