Open AccessGlutathione-Related Antioxidant Defenses in Human Atherosclerotic Plaques
Author(s) -
Domenico Lapenna,
Sergio de Gioia,
Giuliano Ciofani,
Andrea Mezzetti,
S Ucchino,
Antonio M. Calafiore,
Antonio M. Napolitano,
Carmine Di Ilio,
Franco Cuccurullo
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.97.19.1930
Subject(s) - medicine , glutathione , antioxidant , glutathione reductase , glutathione peroxidase , oxidative stress , pathology , endocrinology , biochemistry , enzyme , superoxide dismutase , biology
Oxidative stress, resulting from an antioxidant/prooxidant imbalance, seems to be crucial in atherogenesis. Recent evidence has emerged, however, of a surprisingly high content of low-molecular-weight antioxidants in human atherosclerotic plaques, although other antioxidant systems have not been investigated in these lesions.
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