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Patients with heart failure show a very high incidence of arrhythmias and sudden death that is often preceded by ischemia; however, data on electrophysiological changes during ischemia in failing myocardium are sparse. We studied electrical uncoupling during ischemia in normal and failing myocardium.

Cellular Uncoupling During Ischemia in Hypertrophied and Failing Rabbit Ventricular Myocardium