Open AccessHeterogeneous transmural distribution of beta-adrenergic receptor subtypes in failing human hearts.
Author(s) -
Scott L. Beau,
Timothy Tolley,
Jeffrey E. Saffitz
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.88.6.2501
Subject(s) - medicine , receptor , endocardium , heart failure , endocrinology , adrenergic receptor , beta 1 adrenergic receptor , beta (programming language) , cardiomyopathy , cardiology , radioligand , computer science , programming language
Downregulation of myocardial beta-adrenergic receptor density does not occur in a spatially uniform distribution in patients with congestive heart failure. Rather, it results primarily from loss of receptors in the subendocardium. In patients with dilated cardiomyopathy, beta 1-receptors have been found to be downregulated selectively. These observations suggest that considerable transmural heterogeneity in the distribution of beta-adrenergic receptor subtypes exists in the failing human heart. The present study was designed to test this hypothesis.
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