Open AccessEffect of inotropic stimulation on the negative force-frequency relationship in the failing human heart.
Author(s) -
Robert H. G. Schwinger,
Michael Böhm,
Jochen MüllerEhmsen,
Rainer Uhlmann,
Ulrich Schmidt,
Alexander Stäblein,
P Überfuhr,
E Kreuzer,
Bruno Reichart,
H J Eissner
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.88.5.2267
Subject(s) - contractility , medicine , inotrope , isometric exercise , stimulation , contraction (grammar) , ouabain , isoprenaline , cardiology , endocrinology , heart failure , chemistry , sodium , organic chemistry
In severe human heart failure, an increase in frequency of stimulation is accompanied by a reduced force of contraction in vivo and in vitro. The present study was aimed to investigate whether inotropic stimulation influences the inverse force-frequency relationship in failing human myocardium.
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