Open AccessSerotonin-induced coronary spasm in a swine model. A minor role of defective endothelium-derived relaxing factor.
Author(s) -
Tohru Fukai,
K. Egashira,
Hiroshi Hata,
K Numaguchi,
Yasuhisa Ohara,
Toshinao Takahashi,
H Tomoike,
Akihiro Takeshita
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.88.4.1922
Subject(s) - medicine , constriction , vasodilation , endothelium , serotonin , artery , nitric oxide , cardiology , vasomotor , endothelial dysfunction , anesthesia , vasoconstriction , endocrinology , receptor
Coronary spasm may be caused by endothelial dysfunction, vascular smooth muscle hyperreactivity, or both. We aimed to determine the relative role of endothelial dysfunction and vascular smooth muscle hyperreactivity in the pathogenesis of coronary artery spasm in the swine model in vivo.
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