Open AccessDiminished contractile response to increased heart rate in intact human left ventricular hypertrophy. Systolic versus diastolic determinants.
Author(s) -
C P Liu,
Chih-Tai Ting,
William E. Lawrence,
W L Maughan,
M. S. Chang,
David A. Kass
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.88.4.1893
Subject(s) - medicine , cardiology , diastole , left ventricular hypertrophy , concentric hypertrophy , muscle hypertrophy , blood pressure
Experimental studies indicate that in addition to diastolic dysfunction, hypertrophied myocardium can display depressed contractile responses, particularly at rapid heart rates, compounding reserve limitations. This study tests whether such abnormalities exist in intact human subjects at physiological paced rates and, if so, whether they are linked to simultaneous rate-dependent deterioration in diastolic function.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom