Open AccessShear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.
Author(s) -
Masuo Ohno,
Gary H. Gibbons,
Victor J. Dzau,
John P. Cooke
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.88.1.193
Subject(s) - medicine , pertussis toxin , endocrinology , charybdotoxin , apamin , endothelium , nitric oxide , shear stress , cyclic guanosine monophosphate , channel blocker , biophysics , atrial natriuretic peptide , g protein , calcium , biology , receptor , materials science , composite material
The endothelium acts as the sensor of shear stress and as the mediator of flow-induced changes in vessel tone and structure. The purpose of this study was to delineate the signal transduction pathway of flow-induced release of endothelium-derived relaxing factor (EDRF).
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