Open AccessEffects of calcium and EMD-53998 on oxygen consumption in isolated canine hearts.
Author(s) -
Pieter P. de Tombe,
Daniel Burkhoff,
William C. Hunter
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.86.6.1945
Subject(s) - contractility , inotrope , medicine , calcium , cardiology , cardiac muscle , intracellular , cardiac function curve , cardiac cycle , calcium in biology , heart failure , endocrinology , chemistry , biochemistry
Most positive inotropic agents increase cardiac contractility by increasing the amount of Ca2+ cycled with each beat. The additional amount of oxygen that is consumed by the heart to cycle this additional Ca2+ is believed to reduce myocardial efficiency. On the other hand, it has been suggested that the agent EMD-53998 increases the Ca2+ sensitivity of the contractile proteins without affecting the intracellular Ca2+ transient in cardiac muscle. Therefore, application of this agent may increase cardiac contractility without decreasing myocardial efficiency. The purpose of the present study was to test this hypothesis.
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