Open AccessDifferential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure.
Author(s) -
A T Hirsch,
Chris E. Talsness,
Anita D. Smith,
Heribert Schunkert,
Julie R. Ingelfinger,
Victor J. Dzau
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.86.5.1566
Subject(s) - enalapril , captopril , medicine , heart failure , blood pressure , angiotensin converting enzyme , endocrinology , blood urea nitrogen , plasma renin activity , creatinine , ace inhibitor , excretion , renin–angiotensin system
Angiotensin converting enzyme (ACE) inhibitor therapy elicits beneficial responses from patients with heart failure. We hypothesized that a major site of action of these drugs is tissue ACE and that ACE inhibitors might differ in their ability to inhibit tissue ACE. To test this hypothesis, we assessed the effects of captopril and enalapril on blood pressure and renal function and on serum and tissue ACE activities in sham-operated rats and rats with heart failure induced by coronary artery ligation.
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