Open AccessPrecordial QT interval dispersion as a marker of torsade de pointes. Disparate effects of class Ia antiarrhythmic drugs and amiodarone.
Author(s) -
John T.Y. Hii,
D. George Wyse,
Anne M. Gillis,
Henry J. Duff,
Michale Solylo,
L. Brent Mitchell
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.86.5.1376
Subject(s) - amiodarone , medicine , qt interval , cardiology , repolarization , sotalol , antiarrhythmic agent , prolongation , ventricular tachycardia , torsades de pointes , anesthesia , heart disease , electrophysiology , atrial fibrillation
Patients with a history of class Ia drug-induced torsade de pointes have been treated with chronic amiodarone without recurrence of torsade de pointes despite comparable prolongation of the QT interval. We hypothesized that in such patients, class Ia drugs cause nonhomogeneous prolongation of cardiac repolarization times, whereas amiodarone causes homogeneous prolongation of cardiac repolarization times.
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