Open AccessEndogenous adenosine blunts beta-adrenoceptor-mediated inotropic response in hypoperfused canine myocardium.
Author(s) -
Hideyuki Sato,
M Hori,
Masafumi Kitakaze,
Seiji Takashima,
Michitoshi Inoue,
Akira Kitabatake,
Tomoari Kamada
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.85.4.1594
Subject(s) - medicine , adenosine , prazosin , perfusion , inotrope , coronary perfusion pressure , cardiology , endocrinology , anesthesia , antagonist , receptor , resuscitation , cardiopulmonary resuscitation
Adenosine attenuates beta-adrenoceptor-mediated inotropic responses through GTP-binding protein in vitro. The goal of the present study was to test the hypothesis that endogenous adenosine released from the ischemic myocardium blunts the inotropic response to beta-adrenergic stimulation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom