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T his is not the end; it is not even the beginning of the end; but perhaps it is the end of the beginning. -Winston Churchill 6 June 1944 Gene transfer into tissues of living animals has now been accomplished in several laboratories with the use of a variety of methods.1-4 The initial wave of these reports has been exhilarating and has whetted the appetite for application of these methods to the treatment or prevention of cardiovascular diseases. As the novelty of delivering reporter genes into tissues wears off, it is time to take a hard look at practical issues that will determine the real potential of current gene transfer strategies to address clinical goals.

The end of the beginning. Gene transfer into the vessel wall.