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This article is not a pharmacologic review of angiotensin inhibitors but rather a brief historical overview of the subject as seen from the personal perspective of an investigator involved in the earliest stages of its evolution. This overview follows the steps leading from early observations to controlled studies that unraveled the role of this system in hypertension and its cardiovascular complications; it also speculates on the potential future impact of this work on the incidence of cardiovascular mortality in the hypertensive population

Angiotensin converting enzyme inhibition and its impact on cardiovascular disease.