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Cortisone, whether used prophylactically or therapeutically, did not appear to have any beneficial effect in reducing the size of the myocardial infarcts produced by coronary artery ligation in dogs. No significant differences were noted between the control and cortisone-treated animals in respect to the vascularity of the infarcted area or the rate of healing.

Failure to Reduce the Size of Experimentally Produced Myocardial Infarcts by Cortisone Treatment