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Thevetoidin is a digitalis-like substance isolated from a Mexican species of thevetia. Study of its action on the isolated frog heart, on the anesthetized dog, and on the failing heart of the heart-lung preparation reveals therapeutic and toxic effects of unmistakable digitalis-like character which are quickly established and wear off rapidly. The dose for the treatment of cardiac disorders was deduced from experiments on the failing heart of the heart-lung preparation on the basis of a comparison with ouabain.

The Pharmacologic Action of Thevetoidin, a Cardioactive Substance Obtained from a Mexican Species of Thevetia