Importance of Amino Acid Side Groups for Biologic Activity of Angiotensin II | Zendy

F. Merlin Bumpus | Zendy; Robert R. Smeby | Zendy

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Importance of Amino Acid Side Groups for Biologic Activity of Angiotensin II

Author(s) -

F. Merlin Bumpus,

Robert R. Smeby

Publication year - 1962

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.25.1.183

Subject(s) - medicine , amino acid , renin–angiotensin system , histidine , proline , angiotensin ii , stereochemistry , biochemistry , blood pressure , chemistry

The requirements for biologic activity of angiotensin II may be summarized from available data as follows: (1) a free C-terminal carboxyl group, (2) a phenyl group as a side group of amino acid number 8, (3) a phenolic group on amino acid number 4, (4) proline in position 7, (5) possibly a definite degree of spatial order, (6) at least 6 amino acids from the C-terminus, (7) possibly the imidazole of histidine in position 6.

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