Relationship between Arterial Pressure and Negative U Waves in Electrocardiograms

Direct correlation exists between arterial pressure levels and negativity of U waves in electrocardiograms of hypertensive patients; lowering of arterial pressure results in conversion of negative to positive U waves in the majority of hypertensive patients. Presence of negative U waves does not necessarily indicate organic myocardial changes or a grave prognosis; when their polarity remains unchanged following antihypertensive treatment, it may indicate unsatisfactory control of arterial pressure.