Open AccessSerum Transaminase Levels in Experimental Myocardial Infarction
Author(s) -
Clarence M. Agress,
Howard I. Jacobs,
Harvey F. Glassner,
Marianne Lederer,
WM. G. CLARK,
Felix Wröblewski,
Arthur Karmen,
John S. LaDue
Publication year - 1955
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.11.5.711
Subject(s) - medicine , myocardial infarction , transaminase , cardiology , infarction , autopsy , aspartate transaminase , enzyme , alkaline phosphatase , biochemistry , chemistry
Serum glutamic oxalacetic transaminase concentrations rise sharply after myocardial infarction produced by bead embolization of the coronary tree in the closed chest dog. The peak concentration is reached in 9 to 23 hours post injury. Rises 20 to 30 times greater than normal may be obtained and are directly correlated with the amount of infarction estimated at autopsy. Serial serum transaminase levels may provide a clinical tool to supplement the electrocardiogram in the diagnosis of acute myocardial infarction as well as provide a roughly quantitative estimate of the amount of myocardium involved.
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