Open AccessFlow (Shear Stress)–Induced Endothelium-Dependent Dilation Is Altered in Mice Lacking the Gene Encoding for Dystrophin
Author(s) -
Laurent Loufrani,
Khalid Matrougui,
Diane Gorny,
Micheline Duriez,
Isabelle Blanc,
Bernard Lévy,
Daniel Henrion
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.103.6.864
Subject(s) - dystrophin , mechanotransduction , medicine , vasoconstriction , vascular smooth muscle , anatomy , endothelium , endocrinology , mdx mouse , microbiology and biotechnology , duchenne muscular dystrophy , biology , smooth muscle
Dystrophin has a key role in striated muscle mechanotransduction of physical forces. Although cytoskeletal elements play a major role in the mechanotransduction of pressure and flow in vascular cells, the role of dystrophin in vascular function has not yet been investigated. Thus, we studied endothelial and muscular responses of arteries isolated from mice lacking dystrophin (mdx mice).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom