Open AccessCombination of a Brief Irrigation With Tissue Factor Pathway Inhibitor (TFPI) and Adenovirus-Mediated Local TFPI Gene Transfer Additively Reduces Neointima Formation in Balloon-Injured Rabbit Carotid Arteries
Author(s) -
Nobuhiko Atsuchi,
Takahiro Nishida,
Kousuke Marutsuka,
Yujiro Asada,
Yuichi Kamikubo,
Akira Takeshita,
Hikaru Ueno
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.103.4.570
Subject(s) - tissue factor pathway inhibitor , medicine , saline , tissue factor , coagulation
Tissue factor pathway inhibitor (TFPI) is a physiological antagonist of TF. We tested whether a brief irrigation with TFPI protein (rTFPI) or TFPI gene transfer into injured arteries would suppress TF activity and reduce fibroproliferative changes and investigated whether a combination of these methods would show an additive effect.
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