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The sarcoplasmic reticulum (SR) Ca(2+)-release channel plays a key role in the excitation-contraction coupling of cardiac myocytes. Because respective alterations have been reported in human heart failure, we investigated isoform expression of the SR Ca(2+)-release channel in human hearts from patients with terminal heart failure (dilated cardiomyopathy [DCM], n=8) and nonfailing organ donors (NF, n=8).

Increased Expression of Isoform 1 of the Sarcoplasmic Reticulum Ca 2+ -Release Channel in Failing Human Heart

Increased Expression of Isoform 1 of the Sarcoplasmic Reticulum Ca ²⁺ -Release Channel in Failing Human Heart