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Contrary to beta(1)- and beta(2)-adrenoceptors, beta(3)-adrenoceptors mediate a negative inotropic effect in human ventricular muscle. To assess their functional role in heart failure, our purpose was to compare the expression and contractile effect of beta(3)-adrenoceptors in nonfailing and failing human hearts.

Upregulation of β 3 -Adrenoceptors and Altered Contractile Response to Inotropic Amines in Human Failing Myocardium

Upregulation of β ₃ -Adrenoceptors and Altered Contractile Response to Inotropic Amines in Human Failing Myocardium