Open AccessAerosol Gene Transfer With Inducible Nitric Oxide Synthase Reduces Hypoxic Pulmonary Hypertension and Pulmonary Vascular Remodeling in Rats
Author(s) -
Werner Budts,
Péter Pokreisz,
Zengxuan g,
Natascha Van Pelt,
Hilde Gillijns,
Robert D. Gerard,
Rick Lyons,
Désiré Collen,
Kenneth D. Bloch,
Stefan Janssens
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.102.23.2880
Subject(s) - medicine , pulmonary hypertension , right ventricular hypertrophy , nitric oxide synthase , vascular resistance , pulmonary artery , hypoxia (environmental) , endocrinology , nitric oxide , lung , cardiology , hemodynamics , oxygen , chemistry , organic chemistry
Nitric oxide (NO) is a potent vasodilator with an important role in the regulation of pulmonary vascular tone. The effects of NO synthase (NOS) gene transfer on pulmonary vascular remodeling associated with hypoxic pulmonary hypertension are unknown.
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