Open AccessInsulin Prevents Cardiomyocytes From Oxidative Stress–Induced Apoptosis Through Activation of PI3 Kinase/ Akt
Author(s) -
Ryuichi Aikawa,
Masao Nawano,
Yaping Gu,
Hideki Katagiri,
Tomoichiro Asano,
Weidong Zhu,
Ryozo Nagai,
Issei Komuro
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.102.23.2873
Subject(s) - wortmannin , tunel assay , insulin , oxidative stress , protein kinase b , pi3k/akt/mtor pathway , apoptosis , reactive oxygen species , dna laddering , medicine , endocrinology , myocyte , dna fragmentation , phosphatidylinositol , microbiology and biotechnology , kinase , biology , programmed cell death , biochemistry
Loss of cardiomyocytes by apoptosis is proposed to cause heart failure. Reactive oxygen species induce apoptosis in many types of cells including cardiomyocytes. Because insulin has been reported to have protective effects, we examined whether insulin prevents cardiomyocytes from oxidative stress-induced apoptotic death.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom