Open AccessNoninvasive Ultrasound Imaging of Inflammation Using Microbubbles Targeted to Activated Leukocytes
Author(s) -
Jonathan R. Lindner,
Ji Song,
Fang Xu,
Alexander L. Klibanov,
Kai Singbartl,
Klaus Ley,
Sanjiv Kaul
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.102.22.2745
Subject(s) - microbubbles , medicine , ultrasound , pathology , inflammation , intravital microscopy , myeloperoxidase , ischemia , microcirculation , radiology , immunology
Lipid microbubbles used for perfusion imaging with ultrasound are retained within inflamed tissue because of complement-mediated attachment to leukocytes within venules. We hypothesized that incorporation of phosphatidylserine (PS) into the microbubble shell may enhance these interactions by amplifying complement activation and thereby allow ultrasound imaging of inflammation.
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