Open AccessAltered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca 2+ Leak Through Ryanodine Receptor in Heart Failure
Author(s) -
Masafumi Yano,
Kaoru Ono,
Tomoko Ohkusa,
Masae Suetsugu,
Masateru Kohno,
Takayuki Hisaoka,
Shigeki Kobayashi,
Yuji Hisamatsu,
Takeshi Yamamoto,
Michihiro Kohno,
Naoya Noguchi,
Shin Takasawa,
Hiroshi Okamoto,
Masunori Matsuzaki
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.102.17.2131
Subject(s) - ryanodine receptor , fkbp , heart failure , medicine , endoplasmic reticulum , ryanodine receptor 2 , endocrinology , leak , calcium , chemistry , biochemistry , engineering , environmental engineering
In the pathogenesis of cardiac dysfunction in heart failure, a decrease in the activity of the sarcoplasmic reticulum (SR) Ca(2+)-ATPase is believed to be a major determinant. Here, we report a novel mechanism of cardiac dysfunction revealed by assessing the functional interaction of FK506-binding protein (FKBP12.6) with the cardiac ryanodine receptor (RyR) in a canine model of pacing-induced heart failure.
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