Open AccessCalcineurin Inhibitor Attenuates the Development and Induces the Regression of Cardiac Hypertrophy in Rats With Salt-Sensitive Hypertension
Author(s) -
Masaki Shimoyama,
Doubun Hayashi,
Yunzeng Zou,
Eiki Takimoto,
Miho Mizukami,
Koshiro Monzen,
Sumiyo Kudoh,
Yukio Hiroi,
Yoshio Yazaki,
Ryozo Nagai,
Issei Komuro
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.102.16.1996
Subject(s) - calcineurin , medicine , muscle hypertrophy , endocrinology , fibrosis , pressure overload , cardiac hypertrophy , left ventricular hypertrophy , nfat , cardiac fibrosis , blood pressure , hemodynamics , transplantation
It remains unclear how hemodynamic overload induces cardiac hypertrophy. Recently, activation of calcium-dependent phosphatase, calcineurin, has been elucidated to induce cardiac hypertrophy. In the present study, we examined the role of calcineurin in load-induced cardiac hypertrophy by using Dahl salt-sensitive (DS) rats, which develop both pressure and volume overload when fed a high salt diet.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom