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Platelet adhesion to collagen is the initial step in both hemostasis and thrombosis; this adhesion is mediated by alpha(2)beta(1) on the surface of platelet membranes. An 807 C to T single nucleotide exchange polymorphism close to the gene coding for the alpha(2) subunit of alpha(2)beta(1) is associated with the density of alpha(2)beta(1) on the platelet membrane.

circulation

Homozygosity for 807 T Polymorphism in α 2 Subunit of Platelet α 2 β 1 Is Associated With Increased Risk of Cardiovascular Mortality in High-Risk Women