Open AccessCalcineurin Is Activated in Rat Hearts With Physiological Left Ventricular Hypertrophy Induced by Voluntary Exercise Training
Author(s) -
Yoko Eto,
Katsunori Yonekura,
Makoto Sonoda,
Naoto Arai,
Masataka Sata,
Seiryo Sugiura,
Katsu Takenaka,
Antonio Gualberto,
Mary L. Hixon,
Mark W. Wagner,
Teruhiko Aoyagi
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.101.18.2134
Subject(s) - medicine , calcineurin , cardiology , left ventricular hypertrophy , muscle hypertrophy , endocrinology , constriction , pressure overload , blood pressure , cardiac hypertrophy , transplantation
Calcineurin may play a pivotal role in the signaling of cardiac hypertrophy; since this hypothesis was first put forward, controversial reports have been published using various experimental models. This study was designed to compare the physiological left ventricular hypertrophy (LVH) induced by voluntary exercise with LVH induced by aortic constriction and to determine whether calcineurin participates in the signaling of exercise-induced LVH.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom