Open AccessStimulation of Fecal Steroid Excretion After Infusion of Recombinant Proapolipoprotein A-I
Author(s) -
Mats Eriksson,
Lars A. Carlson,
Tatu A. Miettinen,
Bo Angelin
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.6.594
Subject(s) - cholesterol , excretion , apolipoprotein b , medicine , endocrinology , lathosterol , reverse cholesterol transport , stimulation , feces , lipoprotein , sterol , biology , paleontology , campesterol
Apolipoprotein (apo) A-I is the major protein component of HDL, a cholesterol transport particle that protects against atherosclerosis. Apo A-I is believed to promote reverse cholesterol transport, transferring cholesterol from peripheral cells to the liver for subsequent elimination. To test this hypothesis in humans, we measured fecal steroid excretion before and after the intravenous infusion of human proapo A-I (precursor of apo A-I) liposome complexes.
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