Open AccessRole of C3 Cleavage in Monocyte Activation During Extracorporeal Circulation
Author(s) -
Christine S. Rinder,
Henry M. Rinder,
Kirk W. Johnson,
Michael J. Smith,
David L. Lee,
Jayne B. Tracey,
Glenda Polack,
Paul J. Higgins,
C. Grace Yeh,
Brian R. Smith
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.5.553
Subject(s) - monocyte , complement system , integrin alpha m , downregulation and upregulation , platelet activation , platelet , complement component 5 , chemistry , immunology , pharmacology , medicine , biochemistry , receptor , immune system , gene
We previously demonstrated that inhibiting formation of terminal complement components (C5a and C5b-9) prevents platelet and neutrophil (PMN) but not monocyte activation during simulated extracorporeal circulation (SECC). This study examined whether earlier complement inhibition during SECC, blocking C3a formation, would additionally prevent monocyte activation.
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